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Synthesis of pyrazolo[3,4‐ b ]pyridines and attachment of amino acids and carbohydrate as linkers
Author(s) -
Kendre Dhananjay B.,
Toche Raghunath B.,
Jachak Madhukar N.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450504
Subject(s) - chemistry , yield (engineering) , carbohydrate , amino acid , aqueous solution , sequence (biology) , stereochemistry , organic chemistry , biochemistry , materials science , metallurgy
ynthesis of novel pyrazolo[3,4‐ b ]pyridines has been achieved successfully by sequence of Gould ‐ Jacobs reaction between 5‐aminopyrazole and diethylethoxymethylenemalonate in good yield. Further the pyrazolo[3,4‐ b ]pyridines were converted into succinimidoyl active esters which are then replaced by biological samples such as amino acids and carbohydrate in slightly aqueous medium.