An efficient synthesis of new benzo[1′,2′:6,7]quinolino[2,3‐ d ]‐pyrimidine derivatives  via  three‐component microwave‐assisted reaction | Zendy

Chen Yan | Zendy; Wu Shanshan | Zendy; Tu Shujiang | Zendy; Shi Feng | Zendy; Li Chunmei | Zendy

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An efficient synthesis of new benzo[1′,2′:6,7]quinolino[2,3‐ d ]‐pyrimidine derivatives via three‐component microwave‐assisted reaction

Author(s) -

Chen Yan,

Wu Shanshan,

Tu Shujiang,

Shi Feng,

Li Chunmei

Publication year - 2008

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570450452

Subject(s) - chemistry , pyrimidine , aldehyde , acetic acid , microwave irradiation , yield (engineering) , naphthalene , condensation , condensation reaction , multi component reaction , combinatorial chemistry , organic chemistry , medicinal chemistry , stereochemistry , catalysis , materials science , physics , metallurgy , thermodynamics

A series of benzo[1′,2′:6,7]quinolino[2,3‐ d ]pyrimidine derivatives were synthesized via condensation of an aromatic aldehyde, 2‐hydroxy naphthalene‐1,4‐dione and 2,6‐diaminopyrimidin‐4‐one in mixed solvent of acetic acid and glycol (3:1,V:V) under microwave irradiation. This one‐pot protocol has the advantage of good yield (86‐91%), simple workup procedure and rapid reaction time (4‐8min).

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