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Dichloro dicyano quinone (DDQ) as coupling reagent for high yield synthesis of 3,4‐dihydropyrimidin‐2(1 H )‐ones
Author(s) -
Shobha D.,
Chari M. Adharvana,
Sadanandam P.,
Mukkanti K.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450448
Subject(s) - chemistry , yield (engineering) , acetonitrile , reagent , aldehyde , quinone , urea , condensation , condensation reaction , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis , materials science , physics , metallurgy , thermodynamics
DDQ catalyzes efficiently the three‐component condensation reaction of aldehyde, β‐ketoester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones. Compared to the classical Biginelli reaction conditions, this new approach consistently has the advantage of excellent yields (80‐92%) and short reaction times 1.5‐2.5 h.