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Highly efficient intramolecular cyclizations of 2′‐hydroxychalcones to 4‐chloro‐2 H ‐chromenes under vilsmeier conditions
Author(s) -
Li ZhenHua,
Zheng Cun,
Su WeiKe
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450441
Subject(s) - chemistry , intramolecular force , reagent , medicinal chemistry , combinatorial chemistry , organic chemistry
Highly efficient intramolecular cyclization and of 2′‐hydroxychalcones to 4‐chloro‐2 H ‐chromenes under Vilsmeier conditions have been developed. In comparison with the reported methods, studies carried out indicate that Vilsmeier reagent generated in situ from DMF and bis (trichloromethyl) carbonate (BTC) provides excellent chemselectivity, higher yields and avoids the formation of inorganic phosphorus salts.