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Oxalic acid as a versatile catalyst for one pot facile synthesis of 3,4‐dihydropyrimidin‐2‐(1 H )‐ones and their thione analogues
Author(s) -
Sangshetti Jaiprakash N.,
Shinde Devanand B.,
Kokare Nagnnath D.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450440
Subject(s) - chemistry , thiourea , oxalic acid , catalysis , urea , condensation , organic chemistry , solvent , ethanol , condensation reaction , physics , thermodynamics
3,4‐Dihydropyrimidin‐2‐(1 H )‐ones and their thione analogues are synthesized from the condensation of aromatic aldehydes, β‐dicarbonyl compound and urea or thiourea in presence of 5 mol% of oxalic acid in ethanol‐water (1:2; v/v) under mild reaction conditions. The yields obtained are better and also the use of very inexpensive catalyst, environmentally benign solvent and easy work‐up are the advantageous aspects of the present method.