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Synthesis and anti‐HIV‐1 evaluation of 1,5‐disubstituted pyrimidine‐2,4‐diones
Author(s) -
Loksha Yasser M.,
Globisch Daniel,
Pedersen Erik B.,
La Colla Paolo,
Collu Gabriella,
Loddo Roberta
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450434
Subject(s) - chemistry , pyrimidine , aniline , derivative (finance) , human immunodeficiency virus (hiv) , amine gas treating , halide , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , virology , financial economics , economics , biology
1,5‐Disubstituted pyrimidine‐2,4‐diones were synthesized by fusion of 5‐bromouracil with an aniline derivative followed by coupling with benzyl halide whereas the opposite synthesis sequence failed. Also 4,6‐dichloro‐ N,N ,5‐trimethylpyrimidin‐2‐amine was treated with phenols. The products were tested for their activity against HIV‐1.