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Synthesis of some novel methylene‐bis‐pyrimidinyl‐spiro‐4‐thiazolidinones as biologically potent agents
Author(s) -
Srinivas A.,
Nagaraj A.,
Reddy Ch. Sanjeeva
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450428
Subject(s) - chemistry , thioglycolic acid , methylene , cyclohexanone , guanidine , hydrochloride , antifungal , pyrimidine , methylene blue , elemental analysis , medicinal chemistry , organic chemistry , stereochemistry , catalysis , medicine , dermatology , photocatalysis
A series of novel methylene‐bis‐pyrimidinyl‐spiro‐4‐thiazolidinones 6a‐h have been synthesized by cyclocondensation of thioglycolic acid with methylene‐bis‐( N ‐cyclohexylidene‐ N ‐pyrimidine) 5a‐h , which in turn have been prepared by the reaction of cyclohexanone with methylene‐bis‐2‐aminopyrimidines 4a‐h , which are prepared by the reaction of guanidine hydrochloride with methylene‐bis‐chalcones 3a‐h . The compounds 3a‐h have been synthesized by the reaction of 5‐(3‐formyl‐4‐hydroxybenzyl)‐2‐hydroxybenzaldehyde 2 with various acetophenones in presence of KOH. The compound 2 is prepared by the reported method. The structures of the compounds synthesized have been confirmed by their elemental analysis and spectral data. Their antibacterial and antifungal activities have also been evaluated.