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A green and efficient synthesis of furo[3,4‐ e ]pyrazolo[3,4‐ b ]‐pyridine derivatives in water under microwave irradiation without catalyst
Author(s) -
Shi Feng,
Tu Shujiang,
Jiang Bo,
Li Chunmei,
Zhou Dianxiang,
Shao Qingqing,
Cao Longji,
Wang Qian,
Zhou Jianfeng
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450425
Subject(s) - chemistry , pyridine , catalysis , microwave irradiation , microwave , amine gas treating , organic chemistry , irradiation , nuclear chemistry , medicinal chemistry , nuclear physics , physics , quantum mechanics
A series of furo[3,4‐ e ]pyrazolo[3,4‐ b ]pyridine analogues of podophylloxin were synthesized via three‐component reactions of aldehydes, 3‐methyl‐1‐phenyl‐1 H ‐pyrazol‐5‐amine and tetronic acid in water under microwave irradiation without catalyst. This efficient synthesis not only offers an economical and green synthetic strategy to this class of significant compounds but also enriches the investigations on microwave‐assisted synthesis in water.