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Simple microwave‐assisted ligand‐free suzuki cross‐coupling: Functionalization of halo‐pyrimidine moieties
Author(s) -
Colombo Matteo,
Giglio Marco,
Peretto Ilaria
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450420
Subject(s) - chemistry , pyrimidine , microwave irradiation , combinatorial chemistry , suzuki reaction , surface modification , ligand (biochemistry) , microwave , coupling reaction , organic chemistry , palladium , stereochemistry , catalysis , biochemistry , physics , receptor , quantum mechanics
An advantageous ligand‐free protocol for Suzuki couplings is described. The synthetic procedure entails microwave irradiation for the reduction of the reaction times and the use of silica cartridges for the purification. Dihalo‐pyrimidine structures, interesting scaffolds in medicinal chemistry, were chosen as test compounds.