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Regioselective synthesis of heterocyclic scaffold by aryl radical cyclization
Author(s) -
Majumdar K. C.,
Kundu N.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450414
Subject(s) - chemistry , regioselectivity , coumarin , silica gel , aryl , hydride , aryl radical , combinatorial chemistry , organic chemistry , catalysis , alkyl , hydrogen
Regioselective synthesis of a number of coumarin‐annulated pentacyclic heterocycles have been achieved by tri‐ n ‐butyltin hydride‐mediated aryl radical cyclization. The products are formed as a mixture of cis ‐ and trans ‐ forms which were successfully separated by careful silica gel flash chromatography.