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Preparation of derivatives of 1‐(2‐pyrimidinyl)piperazine as potential antianxiety, antidepressant, and antipsychotic agents
Author(s) -
Becker Irwin
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450410
Subject(s) - piperazine , chemistry , antidepressant , antipsychotic , solvent , pharmacology , organic chemistry , psychiatry , schizophrenia (object oriented programming) , psychology , medicine , anxiety
This paper describes the preparation of twenty‐eight derivatives of 1‐(2‐pyrimidinyl)piperazine as potential antianxiety, antidepressant, and antipsychotic agents. In twenty‐six of the preparations a chloro nitrogen heterocycle was caused to react with an excess of 1‐(2‐pyrimidinyl)piperazine in the absence of solvent. A specific example is given above.