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Synthesis and biological evaluation of novel methylene‐bisthiazolidinone derivatives as potential nematicidal agents
Author(s) -
Srinivas A.,
Nagaraj A.,
Reddy Ch. Sanjeeva
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450409
Subject(s) - chemistry , methylene , microwave irradiation , elemental analysis , condensation , microwave heating , condensation reaction , microwave , primary (astronomy) , combinatorial chemistry , proton nmr , organic chemistry , nuclear chemistry , physics , quantum mechanics , astronomy , thermodynamics , catalysis
In a one pot procedure, a series of novel methylene‐bis‐thiazolidinone derivatives 5 and 6 was prepared by condensation of 5‐(3‐formyl‐4‐methoxybenzyl)‐2‐methoxybenzaldehyde 3 with mercapto acids and primary aromatic amines 4 in presence of ZnCl 2 under both microwave irradiation and conventional heating conditions. High yields are achieved even on a gram scale, while reaction times are considerably shortened under microwave irradiation compared to conventional heating conditions. Characterization of new compounds has been done by means of IR, NMR, MS and elemental analysis. The nematicidal and antibacterial activity of the compounds has also been evaluated.