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A facile synthesis and heteroannulation of thiazolopyrimidine and related heterocyclic systems
Author(s) -
Aly A. A.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450408
Subject(s) - chemistry , reagent , electrophile , nucleophile , methylene , azide , pyrimidine , antimicrobial , combinatorial chemistry , organic chemistry , stereochemistry , catalysis
Reaction of pyrimidinylacetic acid 2 with different electrophilic and nucleophilic reagents gave annulated pyrimidine derivatives 3‐11 , respectively. Compound 3 was transformed to pyrimidinylacetyl azide 12 , which upon heterocyclization with active methylene compounds, acidic and basic reagents furnished functionally substituted heteroaromatic compounds 13‐21 , respectively. The antimicrobial activity of some synthesized compounds was investigated. The structures of the synthesized derivatives were elucidated by elemental and spectral analyses.