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Fused pyridines by a tandem aza‐wittig / heterocyclization strategy: Synthesis of 1,2,4‐triazolo[1,5‐ a ]pyridines and pyrido[1,2‐ b ][1,2,4]triazines
Author(s) -
Barsy Magda A.,
El Rady Eman A.,
El Latif Fawi M. Abd
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450322
Subject(s) - chemistry , wittig reaction , phenylisocyanate , tandem , pyridine , carbon disulfide , ring (chemistry) , medicinal chemistry , organic chemistry , closure (psychology) , materials science , composite material , economics , market economy
The iminophosphorane 1‐amino‐6‐(triphenylphosphoranylideneamino)‐2‐oxo‐4‐phenyl‐1,2‐dihydro‐pyridine‐3,5‐dicarbonitrile 2 prepared from 1,6‐diaminopyridine 1 reacts with heterocumulenes such as carbon disulfide and phenylisocyanate, and with acid chlorides, acid anhydrides and haloketones to give directly the title compounds in an one‐pot aza‐Wittig / heterocyclic‐ring closure process with good yields.