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Microwave assisted synthesis of novel 6,7,8‐trimethoxy N ‐substituted‐4‐aminoquinazoline compounds
Author(s) -
Liu Gang,
Sun Lin,
Liu Chunping,
Ji Chunnuan,
Wen Quanwu,
Ma Songmei
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450320
Subject(s) - chemistry , microwave irradiation , yield (engineering) , isopropyl alcohol , isopropyl , aryl , alcohol , in vitro , combinatorial chemistry , organic chemistry , nuclear chemistry , catalysis , biochemistry , materials science , alkyl , metallurgy
A fast, efficient and convenient reaction of 6,7,8‐trimethoxy‐4‐chloroquinazoline and aryl (or benzyl) amines was achieved under microwave irradiation in isopropyl alcohol, providing a simple method for synthesis of novel 6,7,8‐trimethoxy N ‐substituted‐4‐aminoquinazoline compounds in good yield in short time. The title compounds were evaluated for their in vitro anti‐proliferative activities against PC3 cell by MTT method.