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An Efficient synthesis of pyrimido[4,5‐ b ]quinoline and indeno[2′,1′:5,6]pyrido[2,3‐ d ]pyrimidine derivatives via multicomponent reactions in ionic liquid
Author(s) -
Ji ShunJun,
Ni SaiNan,
Yang Fang,
Shi JingWen,
Dou GuoLan,
Li XiaoYue,
Wang XiangShan,
Shi DaQing
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450310
Subject(s) - chemistry , pyrimidine , quinoline , ionic liquid , aldehyde , bromide , ionic bonding , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry , ion , catalysis
A series of pyrimido[4,5‐ b ]quinoline and indeno[2′,1′:5,6]pyrido[2,3‐ d ]pyrimidine derivatives were synthesized via the three‐component reaction of an aldehyde, 6‐aminopyrimidine‐2,4‐dione and 5,5‐dimethyl‐1,3‐cyclohexanedione or 1,3‐indanedione in ionic liquid 1‐ n ‐butyl‐3‐methylimidazolium bromide ([bmim]Br). This protocol has the advantages of easier work‐up, milder reaction conditions, high yields and an environmentally benign procedure compared with other methods.