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A new, efficient and chemoselective one‐pot protocol for synthesis of 4‐arylidene‐2‐phenyl‐5(4 H )‐oxazolones from aryl aldehyde bisulfite adducts promoted by POCL 3
Author(s) -
Khosropour Ahmad R.,
Khodaei Mohammad M.,
Jomor Seyed J. Hoseini
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450308
Subject(s) - chemistry , aldehyde , chemoselectivity , adduct , aryl , bisulfite , phosphoryl chloride , organic chemistry , chloride , medicinal chemistry , combinatorial chemistry , catalysis , biochemistry , alkyl , gene expression , dna methylation , gene
A one‐pot procedure for the synthesis of 4‐arylidene‐2‐phenyl‐5(4 H )oxazolones directly from aryl aldehyde bisulfite adducts in the absence of Ac 2 O in good to excellent yields using phosphoryl chloride is reported. In addition, the observed chemoselectivity can be considered as a noteworthy advantage of this method.