Premium
Microwave‐assisted döbner synthesis of 2‐phenylquinoline‐4‐carboxylic acids and their antiparasitic activities
Author(s) -
Muscia Gisela C.,
Carnevale Juan P.,
Bollini Mariela,
Asís Silvia E.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450251
Subject(s) - chemistry , trypanosoma cruzi , antiparasitic , leishmania infantum , plasmodium falciparum , microwave irradiation , leishmaniasis , in vitro , malaria , leishmania , carboxylic acid , protozoa , stereochemistry , organic chemistry , biochemistry , microbiology and biotechnology , parasite hosting , visceral leishmaniasis , immunology , biology , medicine , pathology , world wide web , computer science , catalysis
A series of twelve substituted 2‐phenylquinoline‐4‐carboxylic acids analogous to antimalarial and antileishmanial natural products was developed via the Döbner reaction employing microwave irradiation (MW). The products were obtained in moderate yields in 0.5‐3 minutes and nine of them were evaluated in vitro against the parasites responsible for malaria, leishmaniasis and trypanosomiasis diseases (WHO, Switzerland). Four compounds exhibited activity against Trypanosoma cruzi and another two resulted active against Plasmodium falciparum and Leishmania infantum , respectively.