An efficient synthesis of 4‐alkoxy‐5,6‐dihydro‐furo(and ‐thieno)[2,3‐ d ]pyrimidines using zinc chloride/triethylamine reagent system | Zendy

Maruoka Hiroshi | Zendy; Okabe Fumi | Zendy; Yamagata Kenji | Zendy

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An efficient synthesis of 4‐alkoxy‐5,6‐dihydro‐furo(and ‐thieno)[2,3‐ d ]pyrimidines using zinc chloride/triethylamine reagent system

Author(s) -

Maruoka Hiroshi,

Okabe Fumi,

Yamagata Kenji

Publication year - 2008

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570450237

Subject(s) - chemistry , triethylamine , reagent , zinc , alkoxy group , methanol , medicinal chemistry , chloride , ethanol , furan , organic chemistry , alkyl

The one‐pot synthesis of 4‐alkoxy‐5,6‐dihydro‐furo(and ‐thieno)[2,3‐ d ]pyrimidines is described. The reactions of 2‐benzamido‐4,5‐dihydro‐3‐furan(and ‐3‐thiophene)carbonitriles 1a‐d and 2a‐c with ethanol and/or methanol in the presence of zinc chloride and triethylamine gave the corresponding 4‐alkoxy‐5,6‐dihydro‐furo(and ‐thieno)[2,3‐ d ]pyrimidines 3a‐d , 4a‐d , 5a‐c and 6a‐c .

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