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An efficient, “green” approach to aryl amination of cyanuric chloride using acetic acid as solvent
Author(s) -
Kolmakov Kirill A.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450236
Subject(s) - cyanuric chloride , chemistry , amination , acetic acid , aryl , aniline , cyanuric acid , organic chemistry , solvent , reductive amination , environmentally friendly , triazine , chloride , combinatorial chemistry , melamine , catalysis , ecology , alkyl , biology
Acetic acid is an inexpensive and environmentally friendly solvent for facile, clean and high‐yielding aryl amination of cyanuric chloride with aromatic amines, including nitroanilines. Aryl amination in acetic acid medium and isolation protocol are greatly simplified as compared to previously reported procedures. Under proper conditions, it is possible to attach the same or different aniline residues in a controlled way to obtain in excellent yields symmetrical and unsymmetrical 1,3,5‐triazine derivatives, respectively.