Premium
New one step synthesis of 3,5‐disubstituted pyrazoles under microwave irradiation and classical heating
Author(s) -
Outirite Moha,
Lebrini Mounim,
Lagrenée Michel,
Bentiss Fouad
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450231
Subject(s) - chemistry , hydrazine (antidepressant) , hydrate , microwave irradiation , elemental analysis , sulfur , microwave , ethanol , condensation , hydrogen sulfide , irradiation , condensation reaction , sulfide , microwave heating , proton nmr , organic chemistry , combinatorial chemistry , catalysis , chromatography , physics , quantum mechanics , nuclear physics , thermodynamics
A convenient one pot procedure for the synthesis of 3,5‐disubstituted pyrazoles by condensation of chalcones, hydrazine hydrate and sulfur in ethanol under microwave irradiation and conventional heating method is reported. The hydrogen sulfide is produced during the reaction. The pyrazoles are obtained in good yields and excellent state of purity. The structures of new compounds were confirmed by IR, 1 H, and 13 C NMR, MS and elemental analysis.