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Synthesis of azirines containing aldehyde functionality and their utilization as synthetic tools for five membered oxazoles and isoxazoles
Author(s) -
Brahma Sulagna,
Ray Jayanta K.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450203
Subject(s) - chemistry , aldehyde , ring (chemistry) , scope (computer science) , lewis acids and bases , catalysis , combinatorial chemistry , organic chemistry , programming language , computer science
A simple and useful procedure for the synthesis of azirines containing aldehyde functionality from open chain bromo/chloro‐aldehydes at room temperature is reported. The scope of the ring expansion reaction of a number of 3‐substituted‐2‐formyl‐azirines has been examined using different oraganometallic catalysts and a variety of Lewis acids.