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Preparation of 5‐bromo‐6‐phenylimidazo[2,1‐ b ][1,3,4]thiadiazol‐2‐ylamines
Author(s) -
Safarov Saifidin,
Rahmon Rahmonov,
Kukaniev Muhamacho Amadovich,
Schollmeyer Dieter,
Karpuk Elena,
Meier Herbert
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450138
Subject(s) - chemistry , substituent , hydrazine (antidepressant) , crystal structure , primary (astronomy) , stereochemistry , medicinal chemistry , crystallography , physics , chromatography , astronomy
The reaction of primary or secondary amines with 2,5‐dibromo‐6‐phenylimidazo[2,1‐ b ][1,3,4]‐thiadiazole ( 5 ) leads to a chemoselective replacement of the 2‐Br substituent. The process represents a convenient route to the corresponding 2‐ylamines 7a‐d . Hydrazine reacts in an analogous fashion ( 5 → 7e ). The structure determinations are based on an X‐ray crystal structure analysis and on one‐ and two‐dimensional NMR measurements.