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Synthesis and structure of novel 3,4‐annelated coumarin derivatives
Author(s) -
Dekić Milan S.,
Dekić Biljana R.,
Dekić Vidoslav S.,
Deki Stojadin V.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450137
Subject(s) - chemistry , triethylamine , coumarin , acetonitrile , intramolecular force , hydrolysis , condensation , catalysis , proton nmr , organic chemistry , medicinal chemistry , combinatorial chemistry , thermodynamics , physics
Condensation of 4‐chloro‐2‐oxo‐2 H ‐chromene‐3‐carbonitrile ( 1 ) with heteroarylamines 2a‐d in acetonitrile containing a catalytic amount of triethylamine followed by spontaneous intramolecular cyclization gave the novel coumarin derivatives 3a‐d , respectively. These compounds underwent acid hydrolysis giving the corresponding oxoderivatives 4a‐d . The structural assignments of the synthesized compounds were based on elemental, IR, 1 H and 13 C NMR analyses.