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Claisen Condensation of N ‐Methylpyrrolidinone and α‐Chloronicotinic esters
Author(s) -
Kaminski Thomas,
Kirsch Gilbert
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450128
Subject(s) - chemistry , carbanion , nucleophile , pyridine , condensation , halide , organic chemistry , medicinal chemistry , computational chemistry , catalysis , physics , thermodynamics
Reaction between α‐halo‐nicotinic esters and a nucleophilic source such as the N ‐methylpyrrolidin‐2‐one (NMP) gave unexpected results. The presence of the halide on the pyridine gave a very interesting migration reaction. Extension to 6‐methylnicotinic ester derivatives lead to an unexpected carbanion condensation.