Premium
Synthesis and structural study of a new series of 2‐methylsulfanyl‐tetrahydropyrimidines from β‐alkoxyvinyl trihalomethyl ketones
Author(s) -
Zanatta Nilo,
Madruga Claudia C.,
Marisco Patricia C.,
Da Rosa Luciana S.,
Fernandes Liana Da S.,
Flores Darlene C.,
Flores Alex F. C.,
Burrow Robert A.,
Bonacorso Helio G.,
Martins Marcos A P.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450127
Subject(s) - chemistry , series (stratigraphy) , coupling constant , two dimensional nuclear magnetic resonance spectroscopy , proton nmr , sulfate , stereochemistry , computational chemistry , combinatorial chemistry , organic chemistry , paleontology , physics , particle physics , biology
This work describes the synthesis of a novel series of 2‐methylsulfanyl‐tetrahydropyrimidines, from the cyclocondensation reaction of β‐alkoxyvinyl trihalomethyl ketones with 2‐methyl‐2‐thiopseudourea sulfate, in good yields. A detailed 1 H‐ and 13 C‐NMR study was performed on the 2‐methylsulfanyl‐tetrahydropyrimidines obtained and 3D structures were proposed based on AM1 calculations supported by 1 H NMR coupling constants and NOESY experiments.