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Synthesis of enantiomerically pure fire ant venom alkaloids: Solenopsins and isosolenopsins A, B and C
Author(s) -
Bandara Herath H. M. T.,
Dhammika Nanayakkara N. P.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450112
Subject(s) - chemistry , venom , enantiomer , fire ant , stereochemistry , ant , electrophilic substitution , electrophile , alkaloid , organic chemistry , hymenoptera , botany , biochemistry , catalysis , computer network , computer science , biology
Concise and efficient methods for the synthesis of enantiomers of fire ant venom alkaloids solenopsin and isosolenopsin A, B, and C are described. These syntheses are based on diastereoselective electrophilic substitution of enatiomerically‐pure α‐lithiated 2‐alkylpiperidine.