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Synthesis of furanyl and oxazolyl N‐substituted piperidine and imidazoline salts as potential agonists of M 1 muscarinic receptors
Author(s) -
Aguado Andreina,
Boulos John,
Carreras Anladys,
Montoya Angelica,
Rodriquez Judith
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440644
Subject(s) - chemistry , imidazoline receptor , piperidine , iodide , methyl iodide , ethylenediamine , chloride , hydrogen chloride , medicinal chemistry , nuclear chemistry , organic chemistry , pharmacology , medicine
Furanyl and oxazolyl N‐substituted imidazoline salts were prepared by reacting furanyl and oxazolyl esters with ethylenediamine and trimethyl aluminum, followed by the addition of methyl iodide or hydrogen chloride. The piperidinium salts were prepared by treating furanyl and oxazolyl chlorides with piperidine base, followed by the addition of methyl iodide or hydrogen chloride.