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An efficient and facile procedure for the synthesis of 4,6‐diaryl‐2(1 H )‐pyridones under solvent‐free conditions
Author(s) -
Rong Liangce,
Wang Haiying,
Shi Jingwen,
Yang Fang,
Yao Hao,
Tu Shuajiang,
Shi Daqing
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440641
Subject(s) - chemistry , malononitrile , reagent , environmentally friendly , sodium hydroxide , reaction conditions , organic chemistry , solvent , combinatorial chemistry , catalysis , ecology , biology
An efficient and convenient method for the preparation of 4,6‐diaryl‐2(1 H )‐pyridones by the one‐pot reaction of aromatic aldehydes, aromatic ketones and malononitrile, in the presence of sodium hydroxide under solventfree condition is reported. This method has the advantages of good yields, mild reaction conditions, easy workup, inexpensive reagents and being environmentally friendly over the existing procedures.