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Synthesis of 4‐amino‐5,6,7,8‐tetrahydrothieno[2,3‐ b ]quinolin‐5‐ol derivatives
Author(s) -
Song YangHeon,
Seo Jinmoo
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440631
Subject(s) - chemistry , quinoline , yield (engineering) , cyclohexane , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , metallurgy , materials science
This paper describes the synthesis of 4‐amino‐5,6,7,8‐tetrahydrothieno[2,3‐ b ]quinolin‐5‐ol derivatives ( 3a‐h ) and 4‐amino‐5,6,7,8‐tetrahydrothieno[2,3‐ b ]quinoline ( 8a ) in good yield by three‐step procedures starting from 2‐aminothiophene‐3‐carbonitrile and 5‐substituted cyclohexane‐1,3‐dione.
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