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Reactions of aroylthioureas with acetylenic esters and dibenzoyl ethylene. Selectivity towards the formation of new 1,3‐thiazines
Author(s) -
Aly Ashraf A,
Ahmed Essam K.,
ElMokadam Khalad M.
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440630
Subject(s) - chemistry , thiourea , reagent , selectivity , medicinal chemistry , ethylene , organic chemistry , catalysis
A series of 1,3‐thiazines has been synthesized by the reactions of N ‐aroylsubstituted thioureas with ethyl propiolate, dimethyl but‐2‐ynedioate and ( E )‐1,4‐diphenyl‐but‐2‐ene‐1,4‐dione. The reaction of antipyrinylphenyl thiourea with π‐deficient acetylenic reagents did not afford the corresponding 1,3‐thiazines, whereas pyrrolo‐pyrazolopyrimidines were obtained.