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Synthesis of some novel 2,6‐disubstituted pyridazin‐3‐ones as TMC120 analogues
Author(s) -
Loksha Yasser M.,
Pedersen Erik B.,
La Colla Paolo,
Loddo Roberta
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440618
Subject(s) - chemistry , alkylation , aniline , bromide , hydrolysis , derivative (finance) , phenols , benzyl bromide , organic chemistry , stereochemistry , combinatorial chemistry , catalysis , financial economics , economics
Different analogues of TMC120 derived from pyridazin‐3(2 H )‐one rings were synthesized by coupling of 3,6‐dichloropyridazine with arylacetonitriles, phenols and/or aniline derivative followed by hydrolysis and alkylation with different benzyl bromide derivatives.