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Microwaves in organic synthesis: Facile synthesis of biologically active pyridazinone and iminopyridazine derivatives
Author(s) -
Mohamed Nadia Ragab,
ElSaidi Manal Mohamed Talaat,
Ali Yasser Mahmoud,
Elnagdi Mohamed Hilmy
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440615
Subject(s) - chemistry , reagent , wittig reaction , adduct , dimethylformamide , biological activity , microwave , condensation , acetal , organic chemistry , combinatorial chemistry , in vitro , biochemistry , physics , quantum mechanics , solvent , thermodynamics
Condensation of Wittig reagents 1a,b with arylhydrazones 2a,b by conventional and by microwave heating techniques furnished the corresponding pyridazines 3a‐e . The arylhydrazones 7a,b were allowed to react with 1a,b under the same conditions to produce the pyridazinones 10a,b and iminopyridazines 11a,b respectively. On the other hand, the arylhydrazones 12a‐c reacted with 1a to afford the pyridazinones 13a‐c . Treatment of 3b with dimethylformamide dimethyl acetal (DMFDMA) produced the adduct 15 . The utility of microwave heating technique led to the reduction of the reaction times to few minutes and to the improvement of the yields of the products. The in vitro biological activity of some newly prepared compounds against four types of fungi was studied.