Premium
Green synthesis of fused pyrimido derivatives in aqueous medium
Author(s) -
Kidwai Mazaahir,
Singhal Kavita
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440605
Subject(s) - chemistry , phenylhydrazine , potassium carbonate , hydrochloride , hydroxylamine hydrochloride , aqueous solution , barbituric acid , hydrazine (antidepressant) , organic chemistry , green chemistry , ammonia , solvent , potassium hydroxide , catalysis , reaction mechanism , chromatography
The synthesis of nitrogen containing heterocycles from arylidene barbituric acid and various ammonia derivatives such as phenylhydrazine hydrochloride, hydroxylamine hydrochloride and aminoguanidine hydrochloride via a simple and efficient cyclocondensation in an alkaline aqueous medium is described. This improved greener synthetic methodology provides a convenient direct approach using water as a green solvent and potassium carbonate (K 2 CO 3 ) as a green base for the synthesis of pyrazolopyrimidines, isoxazolopyrimidines and pyrimidopyrimidines in excellent yields.