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The synthesis of some 3‐acylindoles revisited
Author(s) -
Hasimbegovic Vedran,
Slätt Johnny,
Bergman Jan,
Janosik Tomasz
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440540
Subject(s) - chemistry , acylation , malonic acid , scope (computer science) , acetic anhydride , acetic acid , organic chemistry , dicarboxylic acid , pummerer rearrangement , combinatorial chemistry , catalysis , computer science , programming language
A study probing the scope of acylation of indoles with dicarboxylic acids in acetic anhydride has been performed, resulting in products incorporating 3‐acylindole‐ or 1‐acylindole motifs depending on the choice of the acid reactant. Synthetically useful results were only obtained from reactions involving malonic acid or Meldrum's acid. Correlations to previous studies have also been made and discussed.