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Microwave assisted synthesis of thiazolo[3,2‐ b ][1,2,4]‐triazoles containing 1,8‐naphthyridine moiety
Author(s) -
Mogilaiah K.,
Prashanthi M.,
Kavitha S.,
Babu H. Sharath
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440530
Subject(s) - chemistry , moiety , methanol , microwave irradiation , aryl , microwave , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , catalysis , alkyl , physics , quantum mechanics
A simple and efficient protocol for the synthesis of 5‐aryl‐2‐(2‐substituted‐1,8‐naphthyridin‐3‐yl)‐thiazolo[3,2‐ b ][1,2,4]triazoles ( 4 ) is achieved by cyclocondensation of 3‐(2‐substituted‐1,8‐naphthyridin‐3‐yl)‐1,2,4‐triazoles ( 3 ) with α‐halogenoketones in anhyd. methanol under microwave irradiation. The products are obtained in good yields and in a state of high purity.