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Synthesis of beta‐proline like derivatives and their evaluation as sodium channel blockers
Author(s) -
Muraglia Marilena,
Franchini Carlo,
Corbo Filomena,
Scilimati Antonio,
Tortorella Vincenzo,
Sinicropi Maria Stefania,
De Luca Annamaria,
De Bellis Michela,
Camerino Diana Conte
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440519
Subject(s) - chemistry , proline , beta (programming language) , optically active , sodium , sodium channel , sodium channel blocker , combinatorial chemistry , stereochemistry , organic chemistry , amino acid , biochemistry , computer science , programming language
A simple and convenient procedure for the preparation of beta‐proline like derivatives in their racemic and optically active forms has been reported. The compounds have been screened for their potential activity as sodium channel blockers.