Premium
One‐pot synthesis of pyrido[2,3‐ d ]pyrimidines via efficient three‐component reaction in aqueous media
Author(s) -
Shi Daqing,
Ji Shunjun,
Niu Lihui,
Shi Jingwen,
Wang Xiangshan
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440517
Subject(s) - chemistry , elemental analysis , alkyl , pyrimidine , aqueous medium , aqueous solution , component (thermodynamics) , chloride , single crystal , proton nmr , nmr spectra database , crystal structure , organic chemistry , medicinal chemistry , combinatorial chemistry , stereochemistry , spectral line , crystallography , physics , astronomy , thermodynamics
A short and facile synthesis of pyrido[2,3‐ d ]pyrimidine derivatives was accomplished in good yields via the three‐component reaction of aldehydes, alkyl nitriles and aminopyrimidines in water in the presence of triethylbenzylammonium chloride (TEBAC). The structures of these compounds were characterized by elemental analysis, IR and 1 H NMR spectra and further confirmed by single crystal X‐ray diffraction analysis.