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Synthesis and antifungal activity of novel 3,6‐diaryl‐5 H ‐[1,2,4]triazolo[4,3‐ b ][1,2,4]triazepines
Author(s) -
Gupta Monika
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440508
Subject(s) - chemistry , antifungal , catalysis , dimethylformamide , microwave irradiation , solvent , elemental analysis , proton nmr , aryl , medicinal chemistry , nuclear chemistry , organic chemistry , medicine , alkyl , dermatology
5‐Aryl‐3,4‐diamino‐1,2,4‐triazoles 5 on treatment with β‐chlorocinnamaldehydes 7 in the presence of catalytic amount of p ‐TsOH and N , N ‐dimethylformamide as an energy transfer medium under microwave irradiation and as solvent with oil‐bath heating at 80 °C affords novel 3,6‐diaryl‐5 H ‐[1,2,4]triazolo[4,3‐ b ]‐1,2,4]triazepines 8 . The structures of the synthesized compounds were established on the basis of 1 H NMR, IR, mass spectral data and elemental analysis.