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A novel synthesis of cyclopropyl lactam and amide from cis ‐2‐aryl‐3‐benzoyl‐1,1‐dicynocyclopropane with H 2 O 2 in the presence of NaHCO 3
Author(s) -
Ren Zhongjiao,
Chen Jie,
Lu Yeying,
Wu Danyi,
Cao Weiguo
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440503
Subject(s) - chemistry , amide , lactam , aryl , stereoselectivity , stereochemistry , medicinal chemistry , organic chemistry , catalysis , alkyl
The process for preparation of cyclopropyl lactam and amide from cis ‐2‐aryl‐3‐benzoyl‐1,1‐dicynocyclopropane with H 2 O 2 in the Presence of NaHCO 3 is described. The highly stereoselective conversion of monocyano group to amide has been carried out in the present method.