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Copper nitrate trihydrate catalyzed efficient synthesis of bis(indolyl)methanes in acetonitrile at room temperature
Author(s) -
Nasreen Aayesha,
Varala Ravi,
Adapa Srinivas R.
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440440
Subject(s) - chemistry , acetonitrile , catalysis , indole test , electrophilic substitution , electrophile , copper , organic chemistry , medicinal chemistry , inorganic chemistry , combinatorial chemistry
A catalytic amount of easily available and inexpensive Cu(NO 3 ) 3 .3H 2 O (10 mol%) enables electrophilic substitution reaction of indole with structurally divergent aldehydes in acetonitrile to afford the corresponding bis(indolyl)methanes in moderate to excellent yields (65‐98%) at ambient temperature. The reaction is highly chemoselective and applicable only to aldehydes and not to ketones.