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Synthesis of new heterocycles containing more than one 1,2,3‐thia or selenadiazole rings
Author(s) -
AlSmadi Mousa
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440427
Subject(s) - chemistry , thionyl chloride , yield (engineering) , ethyl acetoacetate , semicarbazone , alkyl , selenium , chloride , medicinal chemistry , organic chemistry , catalysis , materials science , metallurgy
The diketones 2a‐d with different alkyl chain length are used for the synthesis of di‐1,2,3‐thia or selenadiazole derivatives 4a‐d and 5a‐d . The diketones 2a‐d where prepared by a unique method through the reaction between the corresponding dibromoalkanes 1a‐d and ethyl acetoacetate, which are transformed into the corresponding semicarbazone derivatives 3a‐d . The di‐1,2,3‐thia or selenadiazole derivatives 4a‐d and 5a‐d were prepared from the semicarbazones derivatives 3a‐d on oxidative cyclization with thionyl chloride and selenium dioxide respectively in high yield.