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A facile synthesis of 1‐alkyl‐5‐arylalkoxy‐6‐methoxy‐3,4‐dihydroisoquinolines
Author(s) -
Yim HeongSeup,
Kim HoKyun,
Kim JeumJong,
Kweon DeokHeon,
Yoon YongJin,
Lee SangGyeong,
Kim JungHo
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440426
Subject(s) - chemistry , alkyl , halide , alkylation , potassium carbonate , potassium , organic chemistry , catalysis
1‐Alkyl‐5‐arylalkoxy‐6‐methoxy‐3,4‐dihydroisoquinolines were synthesized by the alkylation of 1‐alkyl‐5‐hydroxy‐6‐methoxy‐3,4‐dihydroisoquinolines with arylalkyl halide in the presence of potassium carbonate. 1‐Alkyl‐5‐hydroxy‐6‐methoxy‐3,4‐dihydroisoquinolines as key precursor prepared from o ‐vaniline via 6 steps.
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