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Synthesis and biological properties of 1,8‐naphthalimidebutylamines. Serotonin 5‐HT 1A and 5‐HT 7 binding data and pass‐assisted search
Author(s) -
Kowalski Piotr,
Kowalska Teresa,
Bojarski Andrzej J.,
Duszyńska Beata
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440423
Subject(s) - chemistry , serotonin , 5 ht receptor , biological activity , stereochemistry , in vitro , tetrahydroisoquinoline , receptor , combinatorial chemistry , biochemistry
yntheses of the N‐substituted butyl derivatives of 1,8‐naphthalimide ( 1‐8 ), containing various arylpiperazines, tetrahydroisoquinoline and methylhomopiperazine moieties attached at 4‐position of the butyl chain have been described. Biological activities were evaluated in vitro for their ability to bind to serotonin 5‐HT 1A and 5‐HT 7 receptors. Due to the structural similarity of derivatives 1‐8 to psychotropic agents, the pharmacological properties of target compounds were predicted using PASS program.