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An efficient microwave‐assisted synthesis of 3,5‐unsubstituted 4‐substituted‐6‐aryl‐3,4‐dihydropyridin‐2(1 H )‐ones derivatives
Author(s) -
Tu Shujiang,
Zhu Xiaotong,
Shi Feng,
Zhang Jinpeng,
Zhang Yan
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440414
Subject(s) - chemistry , ammonium acetate , acetic acid , microwave irradiation , aryl , catalysis , environmentally friendly , organic chemistry , microwave , condensation , combinatorial chemistry , ecology , alkyl , high performance liquid chromatography , physics , thermodynamics , quantum mechanics , biology
mall libraries of 3,5‐unsubstituted 4‐substituted‐6‐aryl‐3,4‐dihydropyridin‐2(1 H )‐ones derivatives were synthesized from the condensation‐products of aldehydes with Meldrum's acid, aromatic ketones and ammonium acetate using acetic acid as energy transferring‐agent under microwave irradiation without catalyst. This method has the advantages of excellent yields (65‐90%), short reaction time (5‐10 min) and being environmentally friendly. It aimed to provide new series of potential biologically active compounds for biomedical screening.