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Selective nucleophilic substitution reactions in 2,4,6‐trisulfanyl‐substituted pyrimidine‐5‐carbonitriles by secondary amines
Author(s) -
Drescher Simon,
Ramsbeck Daniel,
Dobner Bodo,
Briel Detlef
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440402
Subject(s) - chemistry , pyrimidine , alkyl , nucleophilic substitution , medicinal chemistry , organic chemistry , nucleophile , substitution (logic) , stereochemistry , catalysis , computer science , programming language
The highly functionalized heterocycles 6‐alkyl‐ respectively 6‐aralkylsulfanyl‐2,4‐bis‐(amidomethylsulfanyl) pyrimidine‐5‐carbonitriles react selective in the 2‐position with various secondary cyclic amines under mild conditions. The resulting pyrimidines were finally transformed into the corresponding thieno[2,3‐ d ]pyrimidine‐6‐carboxylic acid amides which afford the synthesis of selective substituted thienopyrimidines.