Synthesis of some 2‐oxo and 2‐thioxo substituted pyrimidines using solvent‐free conditions | Zendy

Mobinikhaledi Akbar | Zendy; Forughifar Naser | Zendy; Alipour Safari Jil A. | Zendy; Amini EhsaN. | Zendy

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Synthesis of some 2‐oxo and 2‐thioxo substituted pyrimidines using solvent‐free conditions

Author(s) -

Mobinikhaledi Akbar,

Forughifar Naser,

Alipour Safari Jil A.,

Amini EhsaN.

Publication year - 2007

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570440329

Subject(s) - chemistry , thiourea , aldehyde , recrystallization (geology) , urea , proton nmr , catalysis , solvent , organic chemistry , elemental analysis , ethanol , chloride , nuclear chemistry , paleontology , biology

A series of oxo‐ and thioxopyrimidines 4 ( a‐m ) were synthesized by one‐pot three components cyclocondensation reaction of β‐ketoester, aldehyde and urea/thiourea using benzyltriethylammonium chloride as a catalyst under solvent‐free conditions. The yields of products following recrystallization from ethanol were of the order of 65‐87%. IR and 1 HNMR spectroscopy and elemental analysis were used for identification of these compounds.

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