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Synthesis of some 2‐oxo and 2‐thioxo substituted pyrimidines using solvent‐free conditions
Author(s) -
Mobinikhaledi Akbar,
Forughifar Naser,
Alipour Safari Jil A.,
Amini EhsaN.
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440329
Subject(s) - chemistry , thiourea , aldehyde , recrystallization (geology) , urea , proton nmr , catalysis , solvent , organic chemistry , elemental analysis , ethanol , chloride , nuclear chemistry , paleontology , biology
A series of oxo‐ and thioxopyrimidines 4 ( a‐m ) were synthesized by one‐pot three components cyclocondensation reaction of β‐ketoester, aldehyde and urea/thiourea using benzyltriethylammonium chloride as a catalyst under solvent‐free conditions. The yields of products following recrystallization from ethanol were of the order of 65‐87%. IR and 1 HNMR spectroscopy and elemental analysis were used for identification of these compounds.