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1,3‐dipolar cycloaddition reaction: Synthesis and configuration of norcantharidin derivatives of substituted aromatic amine
Author(s) -
Deng Liping,
Hu Yongzhou
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440314
Subject(s) - chemistry , nitrile , cycloaddition , amine gas treating , 1,3 dipolar cycloaddition , two dimensional nuclear magnetic resonance spectroscopy , combinatorial chemistry , proton nmr , aromatic amine , organic chemistry , stereochemistry , computational chemistry , catalysis
A series of eighteen novel compounds that have potential pharmacological properties has been synthesized by 1,3‐dipolar cycloaddition reactions of 5,6‐dehydronorcantharidin derivatives of substituted aromatic amine with nitrile oxide. The synthesis was carried out following straightforward three‐step procedure described herein. IR, 1 H nmr and ms, H‐H cosy and Noesy Cyclonoe, confirmed the structure of all products respectively. The biological evaluation of three series of norcantharidin analogues against HL60 cell has been screened.