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2‐Vinyl quinazoline 3‐oxides; Preparation from acid induced cyclocondensation of 2‐acylaminoaryloximes
Author(s) -
Heaney Frances,
Lawless Elaine
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440311
Subject(s) - chemistry , moiety , quinazoline , conjugate , organic chemistry , combinatorial chemistry , mathematical analysis , mathematics
2‐Vinyl quinazoline 3‐oxides 6a, 6b and 15a are useful modular building blocks for the construction of a range of heterocycles with potential biological activity, from o ‐[amidoalkenyl]aryloximes 5a, 5b and 14a , respectively, by cyclocondensation. Conjugate addition of EtOH or MeOH to the vinyl moiety of 6b is demonstrated.