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Synthesis of tacrine derivatives under solventless conditions
Author(s) -
Khalilzadeh Mohammad A.,
Hosseini Abolfazl,
Tajbakhsh Mahmoud
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440305
Subject(s) - tacrine , chemistry , yield (engineering) , cyclohexanone , microwave irradiation , microwave heating , organic chemistry , microwave , combinatorial chemistry , catalysis , materials science , physics , quantum mechanics , acetylcholinesterase , metallurgy , enzyme
Effects of microwave irradiation on the solid‐phase synthesis of tacrine and its derivatives have been evaluated. Preparation of tacrine analogues under conventional conditions suffers from poor synthetic efficiency and usually gives low yield. Reaction of substituted anthranilonitrile with cyclohexanone under microwave irradiation gave a good to excellent yield of the corresponding substituted 9‐amino‐1,2,3,4‐tetrahydroacridines.